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Rat CXCL9 (MIG) Recombinant Protein
- Catalog Number:
- RP0917R
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Rattus norvegicus (Norway rat)
- Rat CXCL9 (MIG) (catalog RP0917R) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.0 kDa, 104 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to rat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL9/MIG signaling and immune-cell chemotaxis (including recruitment of activated T cells); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | TLVIRNQRCS CISTSQGTFH YKSLKDLKQF APSPNCNKTE IIATLKNGDQ TCLDPDSARV KKLMKEWEKK ISQKKKQKRG KNHQRSKKTR KAKTPHHPES KKTA (104) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Rat CXCL9 (C-X-C motif chemokine ligand 9), also known as MIG (monokine induced by interferon-γ), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL10 (IP-10) and CXCL11 (I-TAC) that regulate T-cell recruitment during interferon-driven immune responses. In rats (Rattus norvegicus), CXCL9 is produced by macrophages, dendritic cells, endothelial cells, epithelial cells, and fibroblasts in response to interferon-γ (IFN-γ) and inflammatory stimuli during infection or immune activation. CXCL9 signals primarily through the chemokine receptor CXCR3, expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and accumulation of these cells at sites of infection or inflammation. In rat biology, CXCL9 contributes to Th1-type cell-mediated immune responses against intracellular pathogens and plays an important role in inflammatory processes affecting tissues such as the lung, liver, and central nervous system. Rat models have been widely used to study autoimmune and inflammatory diseases, including experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, where CXCL9 participates in the CXCR3-mediated recruitment of T cells into the central nervous system, contributing to neuroinflammation and demyelinating pathology.
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