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Canine IL-17A Recombinant Protein
- Catalog Number:
- RP0920D
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog), Vulpes lagopus (Arctic fox)
- Canine IL-17A (catalog RP0920D) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~14.8 kDa, 127 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to dog, dingo, and Arctic fox. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-17A signaling and inflammatory responses (including regulation of cytokine production and neutrophil recruitment); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | FPQNPGCRNT EDKNFPQHVK VNLNILNRNT NSRRPSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CVNNEGNINY HMNSVPIQQE ILVLRRESQH CPHSFRLEKM LVAVGCTCVT PIVRHVA (127) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 14.8 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays a central role in host defense and inflammatory responses in dogs (Canis lupus familiaris). IL-17A is produced primarily by Th17 cells, as well as by γδ T cells and other innate lymphoid cell populations, in response to microbial infection and inflammatory stimulation. It acts on epithelial, endothelial, and stromal cells to induce the expression of pro-inflammatory cytokines, chemokines (such as CXCL8), and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal and barrier immunity. In healthy dogs, basal IL-17A expression is typically low, but levels increase during bacterial and fungal infections, chronic inflammatory conditions, and immune-mediated diseases. Elevated IL-17A has been implicated in canine atopic dermatitis, inflammatory bowel disease, immune-mediated polyarthritis, chronic rhinitis, and certain autoimmune or inflammatory neurologic disorders. In veterinary and comparative medicine research, canine IL-17A serves as an important biomarker of Th17-mediated immune activation and neutrophilic inflammation, providing insight into disease pathogenesis and potential immunomodulatory therapeutic strategies in canine health.
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