Ovine IL-17A Recombinant Protein

Catalog Number:: RP0922V
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Ovibos moschatus (muskox), Ovis aries (sheep)

Ovine IL-17A (catalog RP0922V) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~14.8 kDa, 130 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to sheep and muskox. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-17A signaling and inflammatory responses (including regulation of cytokine production and neutrophil recruitment); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	GVIIPQSPGC PPTEDKNFPQ HVRVNLNIVN RNTNSRRPTD YHKRSTSPWT LHRNEDPERY PSVIWEAKCS HSGCINAEGK VDHHMNSVTI QQEILVLRRE SQHCPHSFRL EKMLVAVGCT CVTPIVRHVA (130)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	14.8 kda
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Ovine IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays a key role in host defense and inflammatory responses in sheep (Ovis aries). IL-17A is produced primarily by Th17 CD4⁺ T cells, as well as by γδ T cells-which are prominent in ruminants-and other innate lymphoid cell populations in response to microbial infection and immune stimulation. It acts on epithelial, endothelial, and stromal cells to induce expression of pro-inflammatory cytokines (such as IL-6 and TNF-α), chemokines (including CXCL8), and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal and barrier immunity in respiratory, gastrointestinal, and mammary tissues. In healthy sheep, basal IL-17A expression is generally low, but levels increase during bacterial and fungal infections, mastitis, respiratory disease, and parasitic challenges, particularly gastrointestinal nematode infections such as Haemonchus contortus. In veterinary and agricultural research, ovine IL-17A serves as an important biomarker of Th17-mediated immune activation and neutrophilic inflammation, providing insight into host-pathogen interactions, vaccine responses, and immune regulation in small ruminant health and production systems.

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