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Equine IL-12/IL-23 p40 Recombinant Protein
- Catalog Number:
- RP0924E
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Equus caballus (horse) [Gln173Leu]
- Equine IL-12/IL-23 p40 (catalog RP0924E) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~34.9 kDa, 307 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to horse. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-12/IL-23 signaling and immune responses (including regulation of Th1 and Th17 responses and cytokine production); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | IWELEKDVYV VELDWYPDAP GEMVVLTCNT PEEEGITWTS AQSNEVLGSG KTLTIQVKEF GDAGWYTCHK GGEVLSHSHL LLHKKEDGIW STDILKDQKE SKNKTFLKCE AKNYSGRFTC WWLTAISTDL KFSVKSSRGS SDPRGVTCGA ATLSAERVSV DDREYKKYTV ECLEGSACPA AEESLPIEIV VDAVHKLKYE NYTSGFFIRD IIKPDPPKNL QLKPLKNSRQ VEVSWEYPET WSTPHSYFSL TFSIQVQGKN KKERKDRLFM DETSATVTCH KDGQIRVQAR DRYYSSSWSE WASVSCS (307) [Gln173Leu] |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 34.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Equine Interleukin-12/Interleukin-23 p40 (IL-12/IL-23 p40) is a cytokine subunit that plays an important role in regulating immune responses in horses (Equus caballus). The p40 subunit is shared by two heterodimeric cytokines, IL-12 and IL-23, where it pairs with the p35 subunit to form IL-12 and with the p19 subunit to form IL-23. These cytokines are produced primarily by activated antigen-presenting cells, including macrophages and dendritic cells, in response to microbial infection or inflammatory stimuli. Equine IL-12/IL-23 p40 contributes to activation of natural killer (NK) cells and differentiation of T helper cells toward Th1-type immune responses, promoting production of interferon-γ (IFN-γ) and enhancing cell-mediated immunity against intracellular pathogens. Through IL-23 signaling, the p40 subunit also supports maintenance and expansion of Th17 cells involved in inflammatory and host defense pathways. In horses, IL-12/IL-23 p40 participates in immune responses against bacterial, viral, and parasitic infections and is studied in the context of equine diseases such as Rhodococcus equi pneumonia and equine herpesvirus infections. Due to its role in regulating cellular immunity, equine IL-12/IL-23 p40 is widely studied in veterinary immunology and translational research, including investigations of host-pathogen interactions, vaccine responses, and immune-mediated inflammatory conditions relevant to both equine health and comparative biomedical research.
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