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Swine IL-21 Recombinant Protein
- Catalog Number:
- RP0937S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine IL-21 (catalog RP0937S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~15.0 kDa, 129 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-21 signaling and immune-cell function (including regulation of T-cell, B-cell, and NK-cell activity); typical experimental uses include cell-culture stimulation and dosing studies, signaling and functional assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | HKSSFQGQDR LLIRLRQLID TVDQLKNYVH DLDPELLPAP EDVQRHCEQS AFSCFQKVEL KSANTGDNEK IINVLIKQLK RKLPPTNAGR RQKHGLTCPT CDSYEKKPIK EFLERLKSLI QKMIHQHLS (129) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 15.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine IL-21 (Interleukin-21) is a cytokine of the common γ chain (γc) family that plays a central role in regulating adaptive immune responses in pigs (Sus scrofa). IL-21 is produced primarily by activated CD4⁺ T cells, particularly T follicular helper (Tfh) cells and Th17 cells, following antigen stimulation. It signals through the IL-21 receptor (IL-21R) in association with the common γ chain, activating downstream JAK/STAT pathways-predominantly STAT3-to regulate gene expression in B cells, T cells, and natural killer (NK) cells. IL-21 promotes B cell proliferation, plasma cell differentiation, immunoglobulin class switching, and antibody production, while enhancing CD8⁺ T cell cytotoxic activity and NK cell function. In healthy swine, basal IL-21 expression is generally low but increases during infection, vaccination, and immune activation. Altered IL-21 responses have been associated with porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus, African swine fever virus (ASFV), and enteric infections, where effective T cell-dependent antibody responses are critical for protection. Pigs serve as important translational models for human immunology, vaccine development, and mucosal immune research due to similarities in immune system organization. In veterinary and biomedical research, swine IL-21 is studied as a biomarker of T cell-dependent B cell help and humoral immunity and as a key regulator of adaptive immune responses in infectious disease and vaccination models.
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