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Swine Erythropoietin (EPO) Recombinant Protein
- Catalog Number:
- RP0938S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine Erythropoietin (EPO) (catalog RP0938S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.6 kDa, 168 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study EPO signaling and erythropoiesis (including regulation of red blood cell production and survival); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and differentiation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | APPRLICDSR VLERYILEAK EGENATMGCA ESCSFSENIT VPDTKVNFYA WKRMEVQQQA MEVWQGLALL SEAILQGQAL LANSSQPSEA LQLHVDKAVS GLRSLTSLLR ALGAQKEAIP LPDASPSSAT PLRTFAVDTL CKLFRNYSNF LRGKLTLYTG EACRRRDR (168) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine Erythropoietin (EPO) is a glycoprotein hormone belonging to the type I cytokine family that regulates erythropoiesis, the production of red blood cells. In pigs (Sus scrofa), erythropoietin is produced primarily by peritubular interstitial cells in the kidney, with additional production occurring in the liver, in response to hypoxia or reduced oxygen-carrying capacity of the blood. Swine EPO binds to the erythropoietin receptor (EPOR) on erythroid progenitor cells in the bone marrow, activating intracellular signaling pathways such as JAK2-STAT5, PI3K-AKT, and MAPK, which promote the survival, proliferation, and differentiation of erythroid precursor cells into mature red blood cells. In swine physiology, erythropoietin is essential for maintaining normal hematocrit levels and adequate oxygen delivery to tissues, particularly during growth, physiological stress, or blood loss. Because pigs share significant anatomical, physiological, and hematological similarities with humans, they are widely used as translational animal models for studying anemia, kidney disease, and hypoxia-related disorders, and swine models have been used to investigate EPO regulation and erythropoiesis in conditions such as renal anemia and critical illness, providing insights relevant to human hematology and therapeutic EPO use.
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