Swine IL-2 Recombinant Protein

Catalog Number:: RP0939S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Sus scrofa (pig)

Swine IL-2 (catalog RP0939S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~15.2 kDa, 134 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-2 signaling and T-cell biology (including T-cell proliferation, activation, and survival); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and activation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	APTSSSTKNT KKQLEPLLLD LQLLLKEVKN YENADLSRML TFKFYMPKQA TELKHLQCLV EELKALEGVL NLGQSKNSDS ANIKESMNNI NVTVLELKGS ETSFKCEYDD ETVTAVEFLN KWITFCQSIY STLT (134)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	15.2 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Swine IL-2 (Interleukin-2) is a central T cell-derived cytokine that regulates lymphocyte proliferation, differentiation, and immune homeostasis in pigs (Sus scrofa). IL-2 is produced primarily by activated CD4⁺ and CD8⁺ T lymphocytes following antigen recognition and costimulatory signaling. It functions through the IL-2 receptor complex (IL-2Rα/CD25, IL-2Rβ/CD122, and the common γ chain/CD132) to promote clonal expansion of antigen-specific T cells, enhance cytotoxic T lymphocyte and natural killer (NK) cell activity, and support the development and maintenance of regulatory T cells (Tregs), which are essential for immune balance. In healthy swine, basal IL-2 expression is generally low but increases during infection, vaccination, and immune stimulation. Altered IL-2 responses have been associated with porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus, African swine fever virus (ASFV), enteric infections, and immune-mediated inflammatory conditions. Pigs serve as important translational models for human immunology, transplantation research, and vaccine development due to similarities in immune system structure and function. In veterinary and biomedical research, swine IL-2 is widely used as a biomarker of T cell activation and cell-mediated immunity and as a tool for evaluating vaccine efficacy, host-pathogen interactions, and immunomodulatory therapies.

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