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Multi-species (Ovine, Caprine) IL-2 Recombinant Protein
- Catalog Number:
- RP0952V
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Budorcas taxicolor (takin), Capra hircus (goat), Ovis aries (sheep)
- Caprine/Ovine IL-2 (catalog RP0952V) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~15.6 kDa, 135 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to goat, sheep, and takin. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-2 signaling and T-cell biology (including T-cell proliferation, activation, and survival); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and activation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | APTSSSTGNT MKEVKSLLLD LQLLLEKVKN PENLKLSRMH TFNFYMPKVN ATELKHLKCL LEELKLLEEV LDLAPSKNLN TREIKDSMDN IKRIVLELQG SETRFTCEYD DATVKAVEFL NKWITFCQSI YSTMT (135) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 15.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Ovine IL-2 (Interleukin-2) is a central T cell-derived cytokine that regulates lymphocyte proliferation, differentiation, and immune homeostasis in sheep (Ovis aries). IL-2 is produced primarily by activated CD4⁺ and CD8⁺ T lymphocytes following antigen recognition and costimulatory signaling, and it functions through the IL-2 receptor complex (IL-2Rα/CD25, IL-2Rβ/CD122, and the common γ chain/CD132) to promote clonal expansion of antigen-specific T cells, enhance cytotoxic T lymphocyte and natural killer (NK) cell activity, and support development and maintenance of regulatory T cells (Tregs), which are essential for maintaining immune balance. In healthy sheep, basal IL-2 expression is generally low but increases during infection, vaccination, and immune stimulation. Altered IL-2 responses have been associated with ovine lentivirus (maedi-visna), parasitic infections such as Haemonchus contortus, bacterial respiratory disease, and chronic inflammatory conditions. Sheep serve as important large-animal models for respiratory disease, vaccine development, and mucosal immunology. In veterinary and translational research, ovine IL-2 is widely used as a biomarker of T cell activation and cell-mediated immunity and supports studies of host-pathogen interactions, immunoregulation, and vaccine efficacy in small ruminant health.
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