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Rabbit CCL21 Recombinant Protein
- Catalog Number:
- RP0976U
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Oryctolagus cuniculus (rabbit)
- Rabbit CCL21 (catalog RP0976U) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.0 kDa, 108 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to rabbit. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL21 signaling and immune-cell trafficking (including lymphocyte homing and dendritic-cell migration); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SDGGAQDCCL KYSLRKIPHK VVRSYRKQEP SLGCPISAIL FSPRKRSQPE LCADPKEPWV QQLMKRLDRP PAPKKQVQAC RKDGGASKSG KKGKGCKRTE QPQTPKGP (108) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Rabbit CCL21 (C-C motif chemokine ligand 21, also known as secondary lymphoid-tissue chemokine, SLC, or 6Ckine) is a homeostatic chemokine that regulates lymphocyte trafficking and organization of adaptive immune responses in rabbits (Oryctolagus cuniculus). CCL21 primarily signals through the CCR7 receptor, directing the migration of naive T cells, central memory T cells, and mature dendritic cells to secondary lymphoid tissues such as lymph nodes and spleen. In rabbits, CCL21 is produced mainly by stromal cells and endothelial cells within lymphoid organs, where it establishes chemokine gradients that guide immune cells into T-cell zones and facilitate interactions between dendritic cells and lymphocytes required for activation of adaptive immunity. In rabbit health and research, CCL21-mediated CCR7 signaling is important for immune surveillance and lymphoid tissue organization, and it is studied in models of infectious disease, inflammatory responses, and tumor immunology. Because rabbits are commonly used as translational models for immunology, vaccine development, and inflammatory disease, characterization of rabbit CCL21 supports studies of lymphoid architecture, immune cell migration, and adaptive immune responses relevant to both veterinary and human health.
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