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Multi-species (Mouse, Rat) CCL5 (RANTES) Recombinant Protein
- Catalog Number:
- RP0984M
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Arvicanthis niloticus (African grass rat), Mastomys coucha (southern multimammate mouse), Mus caroli (Ryukyu mouse), Mus musculus (house mouse), Rattus norvegicus (Norway rat), Rattus rattus (black rat)
- Mouse/Rat CCL5 (RANTES) (catalog RP0984M) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.9 kDa, 68 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to house mouse, Norway rat, Ryukyu mouse, black rat, African grass rat, and southern multimammate mouse. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL5/RANTES signaling and immune-cell chemotaxis (including recruitment of T cells, eosinophils, and basophils); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS (68) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 7.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Mouse CCL5 (C-C motif chemokine ligand 5, also known as RANTES - Regulated upon Activation, Normal T cell Expressed and Secreted) is a proinflammatory chemokine that plays a central role in immune cell recruitment, antiviral defense, and inflammatory signaling in mice (Mus musculus). CCL5 is a member of the CC chemokine family, which also includes CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL2 (MCP-1), chemokines that regulate leukocyte trafficking during immune responses. In mice, CCL5 is produced primarily by activated T lymphocytes, macrophages, dendritic cells, platelets, epithelial cells, and endothelial cells in response to infection, inflammatory stimuli, or tissue injury. CCL5 exerts its biological effects mainly through binding to the chemokine receptors CCR1, CCR3, and CCR5, promoting chemotaxis and activation of T cells, monocytes/macrophages, eosinophils, and natural killer (NK) cells at sites of inflammation. In murine models, CCL5 plays important roles in host defense against viral, bacterial, and parasitic infections, as well as in chronic inflammatory and autoimmune diseases such as experimental autoimmune encephalomyelitis (a model for multiple sclerosis), asthma models, and inflammatory arthritis. Because mice are the most widely used genetic model organism in immunology, CCL5 has been extensively studied in knockout and transgenic mouse models to understand chemokine-mediated leukocyte trafficking, inflammatory disease mechanisms, and therapeutic targeting of the CCL5-CCR5 pathway relevant to human immune disorders.
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