Feline CD40 Ligand (Yeast-derived Recombinant Protein) - 25 micrograms

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CD40 Ligand (CD40LG) is a transmembrane protein that is a member of the TNF superfamily. In addition to existing in a membrane bound form, CD40LG can also be released as a soluble molecule (sCD40LG), which has been shown to have biological functions.

CD40 interacts with CD40 ligand (aka CD40LG, TNFSF5 or CD154), which is predominantly expressed on activated CD4+ T-cells. CD40LG is transiently expressed on activated T-cells and plays a crucial role in B-cell function. Activated T-cells expressing CD40LG can also interact with CD40 on endothelial cells to induce production of inflammatory cytokines. The transient expression of CD40LG allows T-cells to stimulate selected CD40-bearing cells to participate in the immune response. Increased levels of sCD40LG have been measured in patients with SLE, RA, inflammatory bowel diseases, systemic sclerosis, and Sjogren's syndrome. In culture, canine sCD40LG was shown to promote the maturation and activation of canine monocyte derived Dendritic cells.

Alternate Names - CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand

Homology Across Species
Felis catus (domestic cat) CD40 Ligand – 100%
Panthera pardus (leopard) CD40 Ligand – 100%
Panthera tigris altaica (Amur tiger) CD40 Ligand – 100%
Acinonyx jubatus (cheetah) CD40 Ligand – 100%
Ursus maritimus (polar bear) CD40 Ligand – 95%
Ursus arctos horribilis (grizzly bear) CD40 Ligand – 95%
Ailuropoda melanoleuca (giant panda) CD40 Ligand – 95%
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Feline CD40 Ligand (Yeast-derived Recombinant Protein) - 25 micrograms
Catalog No.:
25 ug
The Feline CD40LG recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
The Feline CD40LG (TNFSF5) recombinant protein has a predicted molecular weight of 15.9 kDa.
Protein Sequence:
Country of Origin:
The feline CD40LG endotoxin-free recombinant protein can be used in cell culture, as an ELISA Standard, and as a Western Blot Control.
None at this time

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