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Swine CX3CL1 (Fractalkine) Recombinant Protein
- Catalog Number:
- RP0991S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine CX3CL1 (Fractalkine) (catalog RP0991S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.8 kDa, 77 amino acids long (chemokine domain; full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CX3CL1/fractalkine signaling and leukocyte trafficking (including adhesion and migration of monocytes, NK cells, and T cells); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QHFGVNKCSI KCSGMTNKMI PLQLLVHYQL PQGSCGQNVV ILKTRKQKLF CADSNEEWVR EAMDYLNRRA DLLGQNG (77) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.8 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine CX3CL1 (C-X3-C motif chemokine ligand 1), also known as fractalkine, is a chemokine belonging to the CX3C chemokine family, characterized by three amino acids separating the first two conserved cysteine residues. CX3CL1 is unique among chemokines because it exists in both a membrane-bound form and a soluble form, allowing it to function in both leukocyte adhesion and chemotaxis. In pigs (Sus scrofa), CX3CL1 is produced primarily by endothelial cells, epithelial cells, neurons, and macrophages in response to infection, inflammatory cytokines, or tissue injury. CX3CL1 binds to its receptor CX3CR1, which is expressed on monocytes, macrophages, natural killer (NK) cells, and subsets of T lymphocytes, promoting adhesion, migration, and activation of immune cells at sites of inflammation. In swine health, the CX3CL1-CX3CR1 pathway contributes to immune responses during respiratory and systemic infections, including diseases such as porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza, where chemokine-mediated leukocyte recruitment helps coordinate inflammatory and antiviral responses in lung tissues. Because pigs share important physiological and immunological similarities with humans, swine CX3CL1 is also studied in translational animal models of cardiovascular disease and inflammatory disorders, particularly in atherosclerosis models, where fractalkine signaling plays a role in monocyte adhesion to vascular endothelium and vascular inflammation.
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