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Swine Leukemia Inhibitory Factor (LIF) Recombinant Protein
- Catalog Number:
- RP1012S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Phacochoerus africanus (Common warthog), Sus scrofa (pig)
- Swine LIF (Leukemia Inhibitory Factor) (catalog RP1012S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~19.7 kDa, 180 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig and warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study LIF signaling and cellular differentiation and survival (including maintenance of stem cell pluripotency and regulation of cell growth and inflammation); typical experimental uses include cell-culture stimulation and dosing studies, signaling and differentiation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SPLSITPVNA TCATRHPCHS NLMNQIKNQL AQLNSSANAL FILYYTAQGE PFPNNLDKLC GPNVTNFPPF HANGTEKARL VELYRIIAYL GASLGNITRD QRSLNPGAVN LHSKLNATAD SMRGLLSNVL CRLCNKYHVA HVDVAYGPDT SGKDVFQKKK LGCQLLGKYK QVISVLARAF (180) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 19.7 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine Leukemia Inhibitory Factor (LIF) is a multifunctional cytokine belonging to the IL-6 family-which includes IL-6, IL-11, oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine factor 1 (CLCF1), and IL-27-and signals through receptor complexes containing the shared gp130 subunit. In pigs (Sus scrofa domesticus), LIF binds to the LIF receptor (LIFR) in association with gp130, activating JAK/STAT3, MAPK, and PI3K signaling pathways that regulate cell survival, differentiation, immune modulation, and tissue repair. Swine LIF plays important roles in reproductive biology, including endometrial receptivity, conceptus development, and embryo implantation, making it highly relevant to fertility management and assisted reproductive technologies in commercial swine production. LIF is also involved in hematopoiesis, stem cell regulation, and modulation of inflammatory responses during respiratory and enteric infections such as porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza, where STAT3-mediated signaling can influence tissue remodeling and immune balance. Dysregulated LIF expression may contribute to fibrosis or tumor progression in certain contexts. As both a regenerative and immunomodulatory cytokine, swine LIF is important in studies of reproductive efficiency, vaccine responses, inflammatory disease mechanisms, and translational large-animal models. Characterization of swine LIF supports comparative research into IL-6 family signaling and development of STAT3-targeted therapeutic strategies relevant to both veterinary and human medicine.
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