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Caprine IL-4 Recombinant Protein
- Catalog Number:
- RP1019G
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Capra hircus (goat)
- Caprine IL-4 (catalog RP1019G) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.6 kDa, 111 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to goat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-4 signaling and immune responses (including regulation of Th2 differentiation, B-cell activation, and antibody production); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | HKCDITLEEI IKMLNILTSQ KNSCMELPVA DVFAAPKNAT EKETFCRAGI ELRRIYRNHM CLNKFLGGLD RNLSSLASKT CSVNEAKTST STLRDLLERL KTIMKEKYSKC (111) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Caprine Interleukin-4 (IL-4) is a Th2-associated cytokine produced primarily by activated CD4⁺ T helper 2 (Th2) cells, mast cells, and basophils in goats (Capra hircus), where it plays a central role in regulating humoral immunity, alternative macrophage activation, and modulation of inflammatory responses. IL-4 signals through receptor complexes containing IL-4Rα paired with the common gamma chain (γc) or IL-13Rα1, activating JAK/STAT6 pathways that promote B-cell proliferation, antibody class switching, and suppression of Th1-associated cytokines such as IFN-γ. In caprine health, IL-4 is particularly important in responses to gastrointestinal nematodes and other parasitic infections, where Th2 polarization supports parasite clearance, mucosal repair, and development of protective antibody responses. IL-4 also influences immune balance during infections such as caprine arthritis encephalitis (CAE), respiratory disease, and mastitis by shaping Th1/Th2 dynamics, which can affect pathogen persistence and inflammatory pathology. While protective in promoting humoral immunity and limiting excessive inflammation, excessive or prolonged IL-4 signaling may impair effective cell-mediated responses against intracellular pathogens. As a biomarker of type 2 immune activation, caprine IL-4 is relevant in vaccine development, host-parasite interaction studies, and genetic selection for disease resilience. Characterization of caprine IL-4 supports veterinary research into cytokine network regulation, immune polarization, and strategies to improve goat health and productivity through balanced immune modulation.
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