Slide 1 of 1 
Caprine IL-13 Recombinant Protein
- Catalog Number:
- RP1020G
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Capra hircus (goat)
- Caprine IL-13 (catalog RP1020G) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.6 kDa, 113 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to goat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-13 signaling and immune responses (including regulation of Th2-mediated inflammation, airway hyperresponsiveness, and fibrosis); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SPSPVPSPSA LKELIEELVN ITQNQVPLCN GSMVWSLNLT SSMYCAALDS LISISNCSVI QRTKRMLSAL CPHKPSAKHV SSEYIRDTKI EVAQFLKDLL RHSRIVFRNE SYN (113) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Caprine Interleukin-13 (IL-13) is a Th2-associated cytokine produced primarily by activated CD4⁺ T helper 2 (Th2) cells and other type 2 immune populations in goats (Capra hircus), where it plays a central role in regulating mucosal immunity, alternative macrophage activation, and tissue remodeling. IL-13 signals through receptor complexes composed of IL-13Rα1 and IL-4Rα, activating JAK/STAT6 pathways that modulate gene expression involved in IgE-associated responses, mucus production, suppression of pro-inflammatory cytokines, and promotion of wound healing and fibrosis. In caprine health, IL-13 is particularly important in immune responses to gastrointestinal nematodes and other parasitic infections, where Th2 polarization supports parasite expulsion and intestinal tissue repair, but excessive or prolonged IL-13 activity may contribute to fibrosis or chronic inflammation. IL-13 may also influence immune regulation during viral infections such as caprine arthritis encephalitis (CAE) and respiratory disease by shaping the balance between Th1 and Th2 responses. As a biomarker of type 2 immune activation, caprine IL-13 is relevant in studies of host-parasite interactions, vaccine efficacy, and immune resilience in small ruminant production systems. Characterization of caprine IL-13 supports veterinary research into cytokine network regulation, disease resistance, and development of targeted immunomodulatory strategies to improve goat health and productivity.
Please choose a size to see price
RELATED MEDIA
