Swine IFN omega 5 Recombinant Protein

Catalog Number:: RP1024S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Sus scrofa (pig)

Swine IFN-ω5 (catalog RP1024S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~19.7 kDa, 171 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study type I interferon signaling and antiviral immune responses (including regulation of innate immunity and gene expression); typical experimental uses include cell-culture stimulation and antiviral assays, signaling and gene-expression studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	GSLGCDLSQN HVHISRKNLV LLHQMRRISP SFCLKDRKDF GLPQEMVDGS HLQKAQAISV LHEMLQQTFL LFHIKRSSAA WDSILLDKLH SGLHQQLEDL DPCLVQEMGE QASALGMAMK KYFQGIHLYL KEKKYSDCAW EIVRVEIMRA LSFSTNLQER LRIMDEHLGS P (171)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	19.7 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Swine Interferon Omega 5 (IFN-ω5) is a type I interferon cytokine involved in the innate antiviral immune response in pigs (Sus scrofa). IFN-ω5 is produced primarily by virus-infected cells and immune cells following recognition of viral nucleic acids by pattern recognition receptors such as Toll-like receptors (TLRs) and RIG-I-like receptors. Swine IFN-ω5 binds to the type I interferon receptor complex (IFNAR1/IFNAR2) expressed on many immune and non-immune cells, activating intracellular signaling through the JAK-STAT pathway, particularly STAT1 and STAT2, which leads to the formation of the ISGF3 transcription complex and induction of numerous interferon-stimulated genes (ISGs) that inhibit viral replication and enhance antiviral defenses. In pigs, IFN-ω5 contributes to the establishment of an antiviral state, modulation of innate and adaptive immune responses, and regulation of inflammatory signaling. Swine IFN-ω5 is studied in veterinary immunology and infectious disease research, particularly in porcine viral disease models such as porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus, where type I interferon responses including IFN-ω5 play an important role in early antiviral immunity and host defense.

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