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Canine IFN beta 1 Recombinant Protein
- Catalog Number:
- RP1026D
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Canis lupus familiaris (dog), Vulpes vulpes (red fox)
- Canine IFN-β1 (catalog RP1026D) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~20.0 kDa, 165 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to dog and red fox. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study type I interferon signaling and antiviral immune responses (including regulation of innate immunity and gene expression); typical experimental uses include cell-culture stimulation and antiviral assays, signaling and gene-expression studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | MSNDLLRSQL SSSSLECQEL LLQLNGTTEY CLKDRINFEI PEEIEKSRQF QKEDIILITH EMFQKIFDIF RRNISRTGWN ETTVENLLVK LHWQKEHLEI ILEDVKEKEN FTWDNRTLLH LKKYYLRIVQ YLKAKEYSIC AWTIVQAEIC RNFFFLNILT DYLQN (165) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 20.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine Interferon-Beta (IFN-β) is a type I interferon produced primarily by virus-infected epithelial cells, fibroblasts, macrophages, and dendritic cells in dogs (Canis lupus familiaris), where it functions as a key early mediator of innate antiviral immunity. Following recognition of viral nucleic acids by pattern recognition receptors such as RIG-I-like receptors and the cGAS-STING pathway, canine IFN-β is rapidly induced and signals through the type I interferon receptor complex (IFNAR1/IFNAR2), activating JAK/STAT signaling and driving expression of interferon-stimulated genes (ISGs) that inhibit viral replication, enhance antigen presentation, and promote activation of natural killer (NK) cells and adaptive immune responses. IFN-β is critically involved in host defense against viral pathogens such as canine parvovirus, canine distemper virus, canine influenza virus, and canine adenovirus, and the magnitude and timing of IFN-β responses can influence disease severity and viral clearance. Dysregulated type I interferon signaling has also been implicated in immune-mediated diseases and inflammatory conditions in dogs. In veterinary and translational research, characterization of canine IFN-β supports studies of antiviral immunity, vaccine development, autoimmune disease mechanisms, and comparative interferon biology, particularly as dogs serve as valuable spontaneous models for human infectious, inflammatory, and immune-mediated diseases.
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