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Feline IL-17A Recombinant Protein
- Catalog Number:
- RP1032F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Felis catus (domestic cat)
- Feline IL-17A (catalog RP1032F) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~15.1 kDa, 130 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-17A signaling and inflammatory responses (including regulation of cytokine production and neutrophil recruitment); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GIAFPQNPGC PTTEDKNFPQ HVKVNVNILN GNKSSRRPLD YYRRSTSPWS LHRNEDPERY PSVIWEAKCL HWGCVNTEGK EDHHMNSVPI QQEILVLRRE SRHCPHSFRL EKMLVTVGCT CVTPIVRHVV (130) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 15.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays an important role in host defense and inflammatory responses in cats (Felis catus). IL-17A is produced primarily by Th17 cells, as well as by γδ T cells and other innate lymphoid populations, in response to microbial infection and inflammatory stimulation. It acts on epithelial, endothelial, and stromal cells to induce expression of pro-inflammatory cytokines, chemokines (such as CXCL8), and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal and barrier immunity. In healthy cats, basal IL-17A expression is typically low, but levels may increase during bacterial or fungal infections, chronic inflammatory conditions, and certain immune-mediated diseases. Elevated IL-17A has been implicated in feline inflammatory bowel disease, chronic gingivostomatitis, asthma, dermatologic inflammation, and possibly tumor-associated inflammation. In veterinary and comparative medicine research, feline IL-17A serves as a biomarker of Th17-mediated immune activation and neutrophilic inflammation, providing insight into mucosal immunity, chronic inflammatory disease pathogenesis, and potential immunomodulatory therapeutic targets in feline health.
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