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Caprine IL-17A Recombinant Protein
- Catalog Number:
- RP1033G
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Capra hircus (goat)
- Caprine IL-17A (catalog RP1033G) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~14.8 kDa, 130 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to goat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-17A signaling and inflammatory responses (including regulation of cytokine production and neutrophil recruitment); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GVIIPQSPGC PPTEDKNFPQ HVRVNLNIVN RNTNSRRPTN YHKRSTSPWT LHRNEDPERY PSVIWEAKCS HSGCINAEGK VDHHMNSVTI QQEILVLRRE SQHCPHSFRL EKMLVAVGCT CVTPIVRHVA (130) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 14.8 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Caprine IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays a critical role in host defense and inflammatory responses in goats (Capra hircus). IL-17A is produced primarily by Th17 cells, as well as by γδ T cells-which are prominent in ruminants-and other innate lymphoid cell populations in response to microbial infection and inflammatory stimulation. It acts on epithelial, endothelial, and stromal cells to induce expression of pro-inflammatory cytokines, chemokines (such as CXCL8), and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal and barrier immunity in the respiratory, gastrointestinal, and mammary tissues. In healthy goats, basal IL-17A expression is generally low, but levels increase during bacterial and fungal infections, mastitis, respiratory disease, and parasitic challenges, particularly gastrointestinal nematode infections. In veterinary and agricultural research, caprine IL-17A serves as an important biomarker of Th17-mediated immune activation and neutrophilic inflammation, providing insight into host-pathogen interactions, vaccine responses, and immune regulation in small ruminant health and production systems.
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