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Swine IL-1 alpha Recombinant Protein
- Catalog Number:
- RP1035S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Phacochoerus africanus (Common warthog), Sus scrofa (pig)
- Swine IL-1α (catalog RP1035S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.1 kDa, 158 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig and warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-1α signaling and inflammatory responses (including regulation of immune-cell activation, cytokine production, and fever responses); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SATYSFQSNM KYNFMRVINH QCILNDARNQ SIIRDPSGQY LMAAVLNNLD EAVKFDMAAY TSNDDSQLPV TLRISETRLF VSAQNEDEPV LLKELPETPK TIKDETSLLF FWEKHGNMDY FKSAAHPKLF IATRQEKLVH MAPGLPSVTD FQILENQS (158) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.1 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine Interleukin-1 Alpha (IL-1α) is a pro-inflammatory cytokine belonging to the IL-1 family-which includes IL-1α, IL-1β, and the IL-1 receptor antagonist (IL-1Ra)-and plays a central role in initiating innate and sterile inflammatory responses in pigs (Sus scrofa domesticus). IL-1α is constitutively expressed in epithelial and barrier tissues and functions as an intracellular alarmin that is rapidly released upon cell injury, necrosis, or viral infection, triggering early inflammatory signaling independent of inflammasome processing. Upon binding to the IL-1 receptor type 1 (IL-1R1), swine IL-1α activates NF-κB and MAPK pathways that promote leukocyte recruitment, endothelial activation, fever, and amplification of pro-inflammatory cytokine cascades. In swine health, IL-1α is particularly relevant in respiratory and enteric diseases such as porcine reproductive and respiratory syndrome (PRRS), swine influenza, African swine fever, bacterial pneumonia, and intestinal infections, where epithelial damage leads to early IL-1α release and contributes to lung or gut inflammation. While essential for pathogen defense and tissue repair, excessive IL-1α signaling can exacerbate tissue injury and impair growth performance. As an early mediator of sterile and infectious inflammation, swine IL-1α serves as a biomarker of tissue damage and innate immune activation. In translational research, pigs are valuable large-animal models due to physiological similarities to humans, and characterization of swine IL-1α supports studies of cytokine-driven inflammation, sepsis, trauma, and development of targeted IL-1-modulating therapies relevant to both veterinary and human medicine.
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