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Swine CCL25 Recombinant Protein
- Catalog Number:
- RP1038S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Phacochoerus africanus (Common warthog), Sus scrofa (pig)
- Swine CCL25 (catalog RP1038S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~6.1 kDa, 52 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig and warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL25 signaling and immune-cell trafficking (including T-cell homing to the gut and thymus); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QGAFEDCCLA YHSHIKWRLL RRAHSYQRQD VSGSCNLPAV IFFFPQKDKM VC (52) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 6.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine CCL25 (C-C motif chemokine ligand 25, also known as TECK - thymus-expressed chemokine) is a homeostatic chemokine that plays a key role in regulation of lymphocyte trafficking and mucosal immune responses in pigs (Sus scrofa domesticus). CCL25 primarily signals through the CCR9 receptor, directing migration of T lymphocytes, particularly gut-homing T cells, to intestinal tissues. In swine, CCL25 is highly expressed in the small intestine and thymus, where it contributes to development and positioning of T cells within mucosal immune compartments and supports immune surveillance at the intestinal barrier. CCL25-mediated CCR9 signaling is important for recruitment of lymphocytes to the gut-associated lymphoid tissue (GALT), facilitating immune responses against enteric pathogens and maintaining intestinal immune homeostasis. In swine health, CCL25 is particularly relevant in enteric infections caused by pathogens such as porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and enterotoxigenic Escherichia coli, where gut-directed immune cell trafficking is critical for mucosal defense and pathogen clearance. Dysregulation of CCL25 expression may influence intestinal inflammation or impaired mucosal immunity. Because pigs are widely used as large-animal models for human gastrointestinal physiology and mucosal immunology, characterization of swine CCL25 supports studies of gut immune cell migration, host-pathogen interactions, and development of mucosal vaccines and therapies relevant to both veterinary and human medicine.
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