Slide 1 of 1 
Canine CXCL13 Recombinant Protein
- Catalog Number:
- RP1046D
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog)
- Canine CXCL13 (catalog RP1046D) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~10.0 kDa, 88 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to dog and dingo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL13 signaling and immune-cell trafficking (including B-cell homing to lymphoid follicles); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | VLEAYNTNLK CKCIQEISGI IPIQLIERLQ IFPPGNGCPK REIIVWKKNK SVVCLNPPIK WTQKLNKILQ KKNATSTQPA PVLKKRIN (88) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 10.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine CXCL13 (C-X-C motif chemokine ligand 13), also known as BCA-1 (B-cell-attracting chemokine 1), is a homeostatic chemokine belonging to the CXC chemokine family that plays a central role in B-cell migration and organization of lymphoid tissues. In dogs (Canis lupus familiaris), CXCL13 is primarily produced by follicular dendritic cells, stromal cells, and macrophages within secondary lymphoid organs, including the lymph nodes, spleen, and mucosal-associated lymphoid tissues. CXCL13 signals through the chemokine receptor CXCR5, which is expressed on B lymphocytes and T follicular helper (Tfh) cells, guiding their migration into lymphoid follicles and germinal centers where antibody-producing B cells develop. In canine immunity, CXCL13 contributes to germinal center formation, B-cell maturation, and humoral immune responses during infection and vaccination. Elevated CXCL13 expression has been associated with chronic inflammatory and infectious diseases, including canine Lyme disease, where CXCL13 in cerebrospinal fluid has been investigated as a biomarker of neuroborreliosis due to its role in recruiting B cells to inflamed nervous tissue. Because of its importance in B-cell trafficking and lymphoid architecture, canine CXCL13 is studied in veterinary immunology, infectious disease research, and biomarker development, helping to improve understanding of B-cell-mediated immune responses and inflammatory disease mechanisms in dogs.
Please choose a size to see price
RELATED MEDIA
