Multi-species (Swine, Rabbit, Dolphin, Bat) IGF-2 Recombinant Protein

Catalog Number:: RP1047
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Balaenoptera acutorostrata scammoni (Minke whale), Castor canadensis (American beaver), Hipposideros armiger (great roundleaf bat), Ictidomys tridecemlineatus (thirteen-lined ground squirrel), Lemur catta (Ring-tailed lemur), Lipotes vexillifer (Yangtze River dolphin), Marmota marmota marmota (Alpine marmot), Microcebus murinus (gray mouse lemur), Orcinus orca (killer whale), Oryctolagus cuniculus (common rabbit), Otolemur garnettii (small-eared galago), Perognathus longimembris pacificus (Pacific pocket mouse), Phacochoerus africanus (Common warthog), Physeter catodon (sperm whale), Propithecus coquereli (Coquerel's sifaka), Rhinolophus ferrumequinum (greater horseshoe bat), Sciurus carolinensis (gray squirrel), Sus scrofa (pig), Tursiops truncatus (bottlenose dolphin), Urocitellus parryii (Arctic ground squirrel)

IGF-2 (catalog RP1047) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.5 kDa, 67 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to rabbit, pig, bottlenose dolphin, great roundleaf bat, greater horseshoe bat, minke whale, American beaver, thirteen-lined ground squirrel, ring-tailed lemur, and gray mouse lemur; this list is not exhaustive, as IGF-2 is highly conserved across more than 30 species. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IGF-2 signaling and growth regulation (including cell proliferation, differentiation, and development); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVNRRSR GIVEECCFRS CDLALLETYC ATPAKSE (67)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	7.5 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Insulin-like Growth Factor 2 (IGF-2) is a peptide growth factor involved in regulating embryonic development, tissue growth, and metabolic processes in swine (Sus scrofa), rabbit (Oryctolagus cuniculus), dolphin (family Delphinidae), and bat (order Chiroptera). The IGF-2 protein is identical at the amino acid level among these species, reflecting strong evolutionary conservation and its essential role in mammalian development. IGF-2 is expressed in multiple tissues, particularly during fetal and early postnatal development, where it promotes cell proliferation, differentiation, and survival. IGF-2 primarily binds to the insulin-like growth factor 1 receptor (IGF1R) and can also interact with the insulin receptor, activating intracellular signaling pathways including PI3K-AKT and MAPK that regulate gene expression, cell growth, and metabolism. In addition, IGF-2 interacts with the IGF-2 receptor (IGF2R), which regulates IGF-2 availability and signaling through ligand internalization and degradation. Across these species, IGF-2 is critical for placental function, fetal growth, and organ development, and it contributes to regulation of muscle development, tissue maintenance, and metabolic homeostasis. Due to its conserved structure and key developmental roles, IGF-2 is widely studied in mammalian physiology, developmental biology, and comparative biomedical research.

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