Slide 1 of 1 
Caprine IL-1 beta Recombinant Protein
- Catalog Number:
- RP1053G
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Budorcas taxicolor (takin), Capra hircus (goat)
- Caprine IL-1β (catalog RP1053G) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.7 kDa, 153 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to goat and takin. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-1β signaling and inflammatory responses (including regulation of immune-cell activation, cytokine production, and fever responses); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | AAVQSVKCKL QDREQKSLVL DSPCVLKALH LLSQEMSREV VFCMSFVQGE ERDNKIPVAL GIRDKNLYLS CVKKGDTPTL QLEEVDPKVY PKRNMEKRFV FYKTEIKNTV EFESVLYPNW YISTSQIEEK PVFLGHFRGG QDITDFRMET LSP (153) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.7 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Caprine Interleukin-1 Beta (IL-1β) is a potent pro-inflammatory cytokine produced primarily by activated macrophages, monocytes, and dendritic cells in goats (Capra hircus) in response to microbial infection, tissue injury, or inflammatory stimuli. Synthesized as an inactive precursor (pro-IL-1β), it is processed into its active form by caspase-1 within the inflammasome complex and signals through the IL-1 receptor (IL-1R1), activating NF-κB and MAPK pathways that promote fever, leukocyte recruitment, endothelial activation, and acute-phase protein production. In caprine health, IL-1β plays a central role in inflammatory responses associated with economically significant diseases such as mastitis, caprine arthritis encephalitis (CAE), pneumonia, caseous lymphadenitis, enteric infections, and parasitic infestations, where it contributes to both pathogen clearance and inflammatory tissue damage. Elevated IL-1β expression in the mammary gland is linked to neutrophil recruitment and severity of intramammary infection. As a biomarker of innate immune activation, caprine IL-1β is valuable for assessing disease progression, vaccine responses, and immune status in herd health management. In veterinary and comparative research, characterization of caprine IL-1β supports studies of inflammasome biology, host-pathogen interactions in small ruminants, inflammatory regulation, and development of targeted immunomodulatory strategies to improve animal health, productivity, and welfare.
Please choose a size to see price
RELATED MEDIA
