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Equine CXCL13 Recombinant Protein
- Catalog Number:
- RP1055E
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Equus caballus (horse), Equus przewalskii (Przewalski's horse)
- Equine CXCL13 (catalog RP1055E) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~10.0 kDa, 88 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to horse and Przewalski's horse. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL13 signaling and immune-cell trafficking (including B-cell homing to lymphoid follicles); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | VLEAYNTNLK CKCIQHTSFF FPIRHIDRVQ IVSPGNGCPN MEVIIWLKNK SVVCLNPKAK STKKLMNVLW RKTFPSTPPT PVSKSMTT (88) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 10.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Ferret CXCL13 (C-X-C motif chemokine ligand 13), also known as BCA-1 (B-cell-attracting chemokine 1), is a homeostatic chemokine belonging to the CXC chemokine family that plays a key role in B-cell migration and organization of lymphoid tissues. In ferrets (Mustela putorius furo), CXCL13 is produced primarily by follicular dendritic cells, stromal cells, and macrophages within secondary lymphoid organs, including the lymph nodes, spleen, and mucosal-associated lymphoid tissues. CXCL13 signals through the chemokine receptor CXCR5, which is expressed on B lymphocytes and T follicular helper (Tfh) cells, directing their migration into lymphoid follicles and germinal centers where antibody responses are generated. In ferret immune responses, CXCL13 contributes to B-cell homing, germinal center formation, and development of humoral immunity during infection or vaccination. Because ferrets are widely used as animal models for respiratory viral diseases, including influenza virus and SARS-CoV-2 infection, CXCL13 has been studied in the context of lymphoid tissue activation and antibody responses in the respiratory tract, where B-cell recruitment and germinal center reactions are important for protective immunity and vaccine evaluation.
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