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Swine CXCL13 Recombinant Protein
- Catalog Number:
- RP1056S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine CXCL13 (catalog RP1056S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~10.0 kDa, 88 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL13 signaling and immune-cell trafficking (including B-cell homing to lymphoid follicles); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | VLETNDTNLK CQCLRSTSNW VPIRLIEKIQ IWPPGNGCPT REVIVWMTNK TAICLNPQSK LLQKLINLMW RKKTSTTLPA PVSKKSIA (88) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 10.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine CXCL13 (C-X-C motif chemokine ligand 13), also known as BCA-1 (B-cell-attracting chemokine 1), is a homeostatic chemokine belonging to the CXC chemokine family that plays a central role in B-cell migration and lymphoid tissue organization. In pigs (Sus scrofa), CXCL13 is produced primarily by follicular dendritic cells, stromal cells, and macrophages within secondary lymphoid organs, including the lymph nodes, spleen, and mucosal-associated lymphoid tissues. CXCL13 signals through the chemokine receptor CXCR5, which is expressed on B lymphocytes and T follicular helper (Tfh) cells, guiding their migration into lymphoid follicles and germinal centers where B cells proliferate, undergo affinity maturation, and differentiate into antibody-producing plasma cells. In swine immunity, CXCL13 plays an important role in germinal center formation, B-cell homing, and development of humoral immune responses during infection or vaccination. Because pigs share important anatomical and immunological similarities with humans, they are used as translational animal models for infectious and mucosal immune responses, including studies of influenza virus and other respiratory pathogens, where CXCL13-mediated B-cell recruitment contributes to lymphoid follicle development and antibody responses in respiratory-associated lymphoid tissues.
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