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Swine Fas Ligand (TNFSF6) Recombinant Protein
- Catalog Number:
- RP1068S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine Fas Ligand (FasL, CD95L, TNFSF6) (catalog RP1068S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.4 kDa, 152 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study Fas/FasL signaling and apoptosis (including regulation of programmed cell death and immune homeostasis); typical experimental uses include cell-culture stimulation and apoptosis assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QIGHPNLPSE KKELRKVAHL TGKPNSRSIP LEWEDTYGIA LVSGVKYMKG SLVINDTGLY FVYSKVYFRG QYCNNQPLSH KVYTRNSRYP QDLVLMEGKM MNYCTTGQMW ARSSYLGAVF NLTSADHLYV NVSELSLVNF EESKTFFGLY KL (152) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine Fas Ligand (FasL, CD95L, gene FASLG) is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily, which includes related ligands such as TNF-α, TRAIL (TNFSF10), and CD40L (CD154) that regulate immune signaling, inflammation, and apoptosis. In pigs (Sus scrofa), Fas ligand is primarily expressed on activated T lymphocytes, cytotoxic T cells, and natural killer (NK) cells, where it interacts with its receptor Fas (CD95) on target cells. Binding of FasL to Fas activates the extrinsic apoptotic pathway, triggering caspase-mediated signaling cascades that induce programmed cell death. In swine immunity, the Fas-FasL system plays an important role in cytotoxic T-cell-mediated elimination of virus-infected or abnormal cells and in maintaining immune homeostasis by removing activated or autoreactive lymphocytes. Because pigs share important physiological and immunological similarities with humans, they are widely used as translational animal models for immunology and transplantation research, and Fas-FasL signaling has been studied in porcine models of organ transplantation, where Fas-mediated apoptosis contributes to regulation of alloreactive immune responses and mechanisms of graft rejection or tolerance, providing insights relevant to human transplant immunology and immune regulation.
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