Slide 1 of 1 
Guinea Pig Leukemia Inhibitory Factor (LIF) Recombinant Protein
- Catalog Number:
- RP1069GP
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Cavia porcellus (domestic guinea pig)
- Guinea Pig LIF (Leukemia Inhibitory Factor) (catalog RP1069GP) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~19.8 kDa, 180 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to guinea pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study LIF signaling and cellular differentiation and survival (including maintenance of stem cell pluripotency and regulation of cell growth and inflammation); typical experimental uses include cell-culture stimulation and dosing studies, signaling and differentiation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SPLPITPVNA TCATRHPCPS NVMSQIRNQL AQLNSSANAL FILYYTAQGE PFPNNLDKLC APNVTDFPPF HANGTEKVKL VELYRIIAYL GAALGNITHD QKLLNPNALS LHSKLSVTAD VMRGLLSNVH CRLCNKYHVA HVDVTYGPDT SDKDVFQKKK LGCQLLGKYK QVIGVVTQAF (180) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 19.8 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Guinea Pig (Cavia porcellus) Leukemia Inhibitory Factor (LIF) is a multifunctional cytokine belonging to the IL-6 family-which includes IL-6, IL-11, oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine factor 1 (CLCF1), and IL-27-and signals through receptor complexes containing the shared gp130 subunit. In guinea pigs, LIF binds to the LIF receptor (LIFR) in association with gp130, activating JAK/STAT3, MAPK, and PI3K signaling pathways that regulate cell survival, differentiation, immune modulation, and tissue repair. Guinea pig LIF is implicated in reproductive biology, including endometrial function and embryo implantation, as well as in hematopoiesis and neural cell maintenance. In infectious disease research, particularly in well-established guinea pig models of tuberculosis, influenza, and other respiratory pathogens, LIF-mediated STAT3 signaling may influence lung inflammation, tissue remodeling, and immune regulation during chronic infection. Dysregulated LIF expression could contribute to fibrosis, granuloma dynamics, or tumor progression in experimental systems. As guinea pigs are valuable translational models for respiratory disease and reproductive biology, characterization of guinea pig LIF supports investigations into IL-6 family cytokine signaling, host-pathogen interactions, stem cell regulation, and development of targeted STAT3-modulating therapies relevant to human inflammatory and fibrotic diseases.
Please choose a size to see price
RELATED MEDIA
