Dolphin Leukemia Inhibitory Factor (LIF) (Yeast-derived Recombinant Protein) - 500 ug (5 x 100 ug vials)

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Leukemia inhibitory factor, or LIF, is a member of the IL-6 family. LIF affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. Leukemia inhibitory factor derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to LIF include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. p53 regulated LIF has been shown to facilitate implantation in the mouse model and possibly in humans. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. LIF is typically added to stem cell culture medium to reduce spontaneous differentiation.

Alternate Names- LIF, CDF, DIA, HILDA, MLPLI, leukemia inhibitory factor, interleukin 6 family cytokine, LIF interleukin 6 family cytokine

LIF Homology Across Species
Delphinapterus leucas (beluga whale) LIF – 100%
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) LIF – 100%
Lagenorhynchus obliquidens (Pacific white-sided dolphin) – 100%
Monodon monoceros (narwhal) LIF – 100%
Globicephala melas (long-finned pilot whale) LIF – 100%
Physeter catodon (sperm whale) LIF – 99%
Orcinus orca (killer whale) LIF – 99%
Lipotes vexillifer (Yangtze River dolphin) LIF – 97%
Camelus ferus (Wild Bactrian camel) LIF – 96%
Camelus bactrianus (Bactrian camel) LIF – 96%
Vicugna pacos (alpaca) LIF – 96%
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Dolphin Leukemia Inhibitory Factor (LIF) (Yeast-derived Recombinant Protein) - 500 ug (5 x 100 ug vials)
Catalog No.:
500 ug (5 x 100 ug vials)
Dolphin LIF was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
Dolphin LIF has a predicted molecular weight of 19.7 kDa.
Protein Sequence:
Country of Origin:
The Dolphin LIF endotoxin-free recombinant protein can be used in cell culture, as an ELISA Standard, and as a Western Blot Control.
None at this time

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