Guinea Pig IL-17A Recombinant Protein

Catalog Number:: RP1082GP
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Cavia porcellus (domestic guinea pig)

Guinea Pig IL-17A (catalog RP1082GP) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~15.1 kDa, 134 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to guinea pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-17A signaling and inflammatory responses (including regulation of cytokine production and neutrophil recruitment); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	GIPIPRNPGC PTATEGKNFL QNVKLNLSIF NPLTQNVNSR RSSDYYKRST SPWTLHRNEN PNRYPPVIWE AECRYSGCVN AAGKEDHHVS SVPIQQEILV LQREPQNCPL SFRLEKMKVT VGCTCVTPIV RHVG (134)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	15.1 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Guinea pig IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays an important role in host defense and inflammatory responses in guinea pigs (Cavia porcellus). IL-17A is produced primarily by Th17 cells, as well as by γδ T cells and other innate lymphoid populations, in response to microbial infection and immune stimulation. It acts on epithelial, endothelial, and stromal cells to induce the expression of pro-inflammatory cytokines, chemokines (such as CXCL8), and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal and barrier immunity, particularly in the respiratory tract. In healthy guinea pigs, basal IL-17A expression is typically low, but levels increase during bacterial infection, allergic airway inflammation, and experimental immune challenge. In biomedical research, guinea pig IL-17A is especially relevant in models of tuberculosis (Mycobacterium tuberculosis), asthma, and allergic airway disease, where Th17-mediated responses contribute to neutrophilic inflammation and granuloma formation. Characterization of IL-17A in guinea pigs provides valuable insight into mucosal immunity, host-pathogen interactions, and inflammatory mechanisms in translational respiratory and infectious disease research.

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