Caprine CCL11 (C-C motif chemokine ligand 11), also known as eotaxin-1, is a member of the CC chemokine family that plays a key role in regulating eosinophil recruitment and type 2–associated immune responses in goats (Capra hircus). CCL11 is produced primarily by epithelial cells, fibroblasts, endothelial cells, and activated immune cells in response to Th2-associated cytokines such as IL-4 and IL-13, and it functions mainly through the CCR3 receptor to promote chemotaxis and activation of eosinophils, as well as certain Th2 lymphocytes and basophils. In healthy goats, basal CCL11 expression is generally low, but levels increase during parasitic infections—particularly gastrointestinal nematode infections such as Haemonchus contortus—as well as during allergic-type inflammation, respiratory disease, and mucosal immune activation. In veterinary and agricultural research, caprine CCL11 serves as a biomarker of Th2-skewed immunity and eosinophilic inflammation, providing insight into host defense against helminths, mucosal immune regulation, and strategies to enhance parasite resistance and vaccine efficacy in small ruminant production systems.