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Human CCL11 (Eotaxin-1) Recombinant Protein
- Catalog Number:
- RP1085H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Homo sapiens (human), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee)
- Human CCL11 (Eotaxin-1) (catalog RP1085H) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.4 kDa, 74 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human, chimpanzee, and pygmy chimpanzee. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL11/eotaxin signaling and immune-cell chemotaxis (including eosinophil recruitment and activation); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP (74) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human CCL11 (C-C motif chemokine ligand 11), also known as eotaxin-1, is a member of the CC chemokine family that plays a central role in regulating eosinophil recruitment and type 2-associated immune responses. CCL11 is produced primarily by epithelial cells, fibroblasts, endothelial cells, smooth muscle cells, and activated immune cells in response to Th2-associated cytokines such as IL-4 and IL-13, as well as inflammatory stimuli. It functions predominantly through the CCR3 receptor to promote chemotaxis and activation of eosinophils, and also influences basophils and certain Th2 lymphocytes. In healthy individuals, circulating CCL11 levels are typically low, but concentrations increase during allergic inflammation, parasitic infection, and certain chronic inflammatory conditions. Elevated CCL11 has been implicated in asthma, allergic rhinitis, atopic dermatitis, eosinophilic esophagitis, inflammatory bowel disease, and some neuroinflammatory and aging-related processes. In clinical and translational research, human CCL11 serves as an important biomarker of eosinophilic inflammation and Th2-driven immune responses and represents a potential therapeutic target for allergic and eosinophil-associated diseases.
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