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Bovine CXCL13 Recombinant Protein
- Catalog Number:
- RP1086B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos indicus (zebu), Bos taurus (cattle)
- Bovine CXCL13 (catalog RP1086B) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~9.9 kDa, 87 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle and zebu. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL13 signaling and immune-cell trafficking (including B-cell homing to lymphoid follicles); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | VLETNNTNLK CKCIRKTVSF FPVNLIERLN IIPRGRGCPN TEIIVWMKNK LVICLNPQAK WTQTLIKVLS KRILSTSPAP VVKKRSD (87) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 9.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CXCL13 (C-X-C motif chemokine ligand 13), also known as BCA-1 (B-cell-attracting chemokine 1), is a homeostatic chemokine belonging to the CXC chemokine family that plays a critical role in B-cell migration and lymphoid tissue organization. In cattle (Bos taurus), CXCL13 is produced primarily by follicular dendritic cells, stromal cells, and macrophages within secondary lymphoid tissues such as the lymph nodes, spleen, and Peyer's patches. CXCL13 signals through the chemokine receptor CXCR5, which is expressed on B lymphocytes and subsets of T follicular helper (Tfh) cells, directing their migration into lymphoid follicles and germinal centers where antibody responses are generated. In bovine immunity, CXCL13 plays an important role in B-cell homing, germinal center formation, and development of humoral immune responses during infection or vaccination. This chemokine is particularly relevant in immune responses against bacterial and viral pathogens affecting cattle, including those associated with bovine respiratory disease and gastrointestinal infections, where effective antibody production is essential for pathogen clearance. Because CXCL13 regulates B-cell trafficking and lymphoid tissue architecture, bovine CXCL13 is studied in veterinary immunology, vaccine response research, and host-pathogen interaction studies to better understand mechanisms controlling humoral immunity and lymphoid organ function in cattle.
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