Slide 1 of 1 
Swine CCL11 (Eotaxin-1) Recombinant Protein
- Catalog Number:
- RP1087S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine CCL11 (Eotaxin-1) (catalog RP1087S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.4 kDa, 74 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL11/eotaxin signaling and immune-cell chemotaxis (including eosinophil recruitment and activation); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QPASVATICC FNVTRKKIPT QRLQSYQRVT ANKCPQNAVI FSTRQAKKIC ADAQENWVQN AMEYLDQKSK TVKS (74) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine CCL11 (C-C motif chemokine ligand 11), also known as eotaxin-1, is a member of the CC chemokine family that regulates eosinophil recruitment and type 2-associated immune responses in pigs (Sus scrofa). CCL11 is produced primarily by epithelial cells, fibroblasts, endothelial cells, smooth muscle cells, and activated immune cells in response to Th2-associated cytokines such as IL-4 and IL-13, as well as inflammatory stimuli. It functions predominantly through the CCR3 receptor to promote chemotaxis and activation of eosinophils, and can also influence basophils and certain Th2 lymphocytes. In healthy swine, basal CCL11 expression is generally low, but levels may increase during parasitic infections-particularly helminth infections affecting the gastrointestinal or respiratory tract-as well as during allergic-type inflammation and mucosal immune activation. In veterinary and translational research, swine CCL11 is of interest in studies of parasite immunity, airway inflammation, gut barrier function, and Th2-biased immune responses, particularly given the physiological similarities between pigs and humans. Characterizing CCL11 expression in swine provides valuable insight into eosinophil biology, chemokine-mediated leukocyte trafficking, and regulation of type 2 inflammatory responses in both agricultural and biomedical research settings.
Please choose a size to see price
RELATED MEDIA
