Mouse CXCL11 (C-X-C motif chemokine ligand 11), also known as I-TAC (Interferon-inducible T-cell alpha chemoattractant), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL10 (IP-10) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In mice (Mus musculus), CXCL11 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon signaling, viral infection, or inflammatory cytokines. CXCL11 signals through the chemokine receptor CXCR3, expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In murine models, CXCL11 contributes to Th1-type immune responses and antiviral immunity, particularly in tissues such as the lung and central nervous system. Mouse CXCL11 has been studied in experimental autoimmune encephalomyelitis (EAE), a widely used animal model of human multiple sclerosis, where CXCL11 participates in the CXCR3-mediated recruitment of T cells into the central nervous system, contributing to neuroinflammation and demyelinating pathology. These studies make mouse CXCL11 important for understanding chemokine-driven T-cell trafficking, interferon-mediated immunity, and mechanisms of inflammatory disease.