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Dolphin IL-13 Recombinant Protein
- Catalog Number:
- RP1094P
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Globicephala melas (long-finned pilot whale), Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise), Orcinus orca (killer whale), Phocoena sinus (vaquita), Tursiops truncatus (common bottlenose dolphin)
- Dolphin IL-13 (catalog RP1094P) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.4 kDa, 112 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to common bottlenose dolphin, killer whale, long-finned pilot whale, vaquita, and Yangtze finless porpoise. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-13 signaling and immune responses (including regulation of Th2-mediated inflammation and cytokine production); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GPVPPSTALK ELIEELVNIT QNQKAPLCNG SMVWSVNLTA NMYCSALEAL INVSNCSAIQ RTQRMLSALC LHKPSAGQVS SEHIRDTKIE VAHFLKDLLK HSRIIFHYGK FS (112) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Dolphin Interleukin-13 (IL-13) is a Th2-associated cytokine produced primarily by activated CD4⁺ T helper cells and other type 2 immune populations in dolphins, particularly the bottlenose dolphin (Tursiops truncatus), where it plays a role in regulating mucosal immunity, alternative macrophage activation, and tissue remodeling. IL-13 signals through receptor complexes containing IL-13Rα1 and IL-4Rα, activating JAK/STAT6 pathways that modulate gene expression involved in IgE-associated responses, mucus production, suppression of pro-inflammatory cytokines, and promotion of wound healing. In dolphin health, IL-13 may be particularly relevant in responses to parasitic infections, chronic dermatitis, respiratory disease, and tissue repair following injury, where balanced type 2 immune responses help limit tissue damage while supporting recovery. Dysregulated IL-13 expression could contribute to fibrosis or chronic inflammatory conditions, especially in the context of environmental stressors such as pollutant exposure or harmful algal blooms. As dolphins serve as sentinel species for marine ecosystem health, IL-13 represents an important biomarker of Th2 immune polarization and inflammatory regulation in both managed and wild populations. Characterization of dolphin IL-13 supports studies of host-pathogen interactions, immune adaptation to marine environments, and comparative type 2 immune mechanisms relevant to both wildlife conservation and broader mammalian immunology.
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