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Ovine IL-13 Recombinant Protein
- Catalog Number:
- RP1097V
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Ovis aries (sheep)
- Ovine IL-13 (catalog RP1097V) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.4 kDa, 114 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to sheep. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-13 signaling and immune responses (including regulation of Th2-mediated inflammation and cytokine production); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SPNPVPSSSS LKELIEELVN ITQNQKVPLC NGSMVWSLNL TSSMYCAALD SLISISNCSV IHRTKRMLSA LCPHKPSAKH VSSEYVRDTK IEVAQFLKDL LRHSRIIFRN GSYN (114) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Ovine Interleukin-13 (IL-13) is a Th2-associated cytokine produced primarily by activated CD4⁺ T helper 2 (Th2) cells and other type 2 immune populations in sheep (Ovis aries), where it plays a central role in regulating mucosal immunity, alternative macrophage activation, and tissue remodeling. IL-13 signals through receptor complexes composed of IL-13Rα1 and IL-4Rα, activating JAK/STAT6 pathways that promote IgE-associated responses, mucus production, suppression of certain pro-inflammatory cytokines, and support of wound healing and fibrotic processes. In ovine health, IL-13 is particularly important in immune responses to gastrointestinal nematodes and other parasitic infections, where Th2 polarization facilitates parasite expulsion and intestinal repair. IL-13 may also influence immune regulation in respiratory disease, mastitis, and chronic viral infections such as ovine progressive pneumonia (maedi-visna) by shaping the Th1/Th2 balance. While protective in limiting excessive inflammation and supporting tissue repair, prolonged or dysregulated IL-13 expression can contribute to fibrosis and chronic inflammatory pathology. As a biomarker of type 2 immune activation, ovine IL-13 is valuable in studies of host-parasite interactions, vaccine development, and genetic selection for disease resilience. Characterization of ovine IL-13 supports veterinary research into cytokine network regulation, mucosal immunity, and strategies to improve flock health and productivity.
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