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Feline BAFF Recombinant Protein
- Catalog Number:
- RP1098F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Felis catus (domestic cat)
- Feline BAFF (B-cell Activating Factor, TNFSF13B) (catalog RP1098F) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.1 kDa, 152 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study BAFF signaling and B-cell biology (including B-cell survival, maturation, and antibody production); typical experimental uses include cell-culture stimulation and dosing studies, signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | AALDPEDTVI QDCLQLIADS DTPTIRKGAY TFVPWLLSFK RGRALEEKEN KILVKETGYF FIYGQVLYTD NTFAMGHLIQ RKKVHVFGDE LSLVNLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PREDAKISQD GDGTFFGALK LL (152) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline BAFF (B cell-Activating Factor), also known as BLyS or TNFSF13B, is a member of the tumor necrosis factor (TNF) superfamily and plays a central role in B cell development, survival, and humoral immunity in cats (Felis catus). BAFF is produced primarily by monocytes, macrophages, dendritic cells, and certain stromal cells, and it signals through the receptors BAFF-R (TNFRSF13C), TACI (TNFRSF13B), and BCMA (TNFRSF17) to promote peripheral B cell maturation, immunoglobulin class switching, and the maintenance of long-lived plasma cells. In healthy cats, BAFF supports normal antibody production and immune homeostasis; however, dysregulated or elevated BAFF expression may contribute to excessive B cell activation and autoantibody production. In veterinary and comparative medicine research, feline BAFF is particularly relevant in naturally occurring diseases such as feline immunodeficiency virus (FIV) infection, feline leukemia virus (FeLV) infection, feline infectious peritonitis (FIP), chronic inflammatory conditions, and B cell-derived malignancies including lymphoma and multiple myeloma. Characterization of feline BAFF provides valuable insight into B cell-mediated immune regulation, chronic infection-associated immune dysregulation, and potential therapeutic strategies targeting BAFF signaling in feline and translational immunology research.
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