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Canine TNFSF11 (RANKL) (Yeast-derived Recombinant Protein) - 25 micrograms

RP1106D-025
$300.00
In Stock
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Bulk quantities of proteins are available. Please contact us for bulk pricing.

Tumor necrosis factor ligand superfamily member 11 (TNFSF11) also known as Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF) is a member of the tumor necrosis factor ligand (TNF) ligand family. Nineteen cytokines have been identified as part of the TNF family on the basis of sequence, functional, and structural similarities. Family members include TNF beta (TNFSF1), TNF alpha (TNFSF2), Lymphotoxin beta (TNFSF3), OX40 Ligand (TNFSF4), CD40 Ligand (TNFSF5), Fas Ligand (TNFSF6), CD27 Ligand (TNFSF7), CD30 Ligand (TNFSF8), 4-1BB Ligand (TNFSF9), TRAIL (TNFSF10), TRANCE/RANKL (TNFSF11), TWEAK (TNFSF12), APRIL(TNFSF13), BAFF (TNFSF13B), LIGHT (TNFSF14), TL1A/VEGI (TNFSF15), and GITR Ligand (TNFSF18). RANKL regulates bone remodelling and the development of the thymus, lymph nodes and mammary glands. Overproduction of RANKL is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and psoriatic arthritis.

Alternate Names - TNFSF11, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNLG6B, tumor necrosis factor superfamily member 11, TNF superfamily member 11

Homology Across Species
Canis lupus familiaris (dog) RANKL – 100%
Mustela putorius furo (domestic ferret) RANKL – 99%
Odobenus rosmarus divergens (Pacific walrus) RANKL – 99%
Felis catus (domestic cat) RANKL – 98%
Leptonychotes weddellii (Weddell seal) RANKL – 98%
Neomonachus schauinslandi (Hawaiian monk seal) RANKL – 98%
Panthera pardus (leopard) RANKL – 98%
Panthera tigris altaica (Amur tiger) RANKL – 98%
Ursus maritimus (polar bear) RANKL – 98%

Canine TNFSF11 (RANKL) (Yeast-derived Recombinant Protein) - 25 micrograms
Catalog No.:
RP1106D-025
Quantity:
25 ug
Source:
The Canine TNFSF11 recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Canine TNFSF11 (RANKL) recombinant protein has a predicted molecular weight of 19.8 kDa.
Protein Sequence:
EKAMMEGSWL EMARRGKTHT QPFAHLTINA TDIPSGSHKV SLSSWYHDRG WAKISNMTFS NGKLIVNQDG FYFLYANICF RHHETSGDLA TEYLQLMVYV TKTSIKIPSS HTLMKGGSTK YWSGNSEFHF YSINVGGFFK LRSGEEISIE VSNPSLLDPD QDATYFGAFK VLDID (175)
Alias:
RANKL, TRANCE, OPGL
Country of Origin:
USA
Applications:
The Canine TNFSF11 (RANKL, TRANCE, OPGL) endotoxin-free recombinant protein can be used in cell culture, as an TNFSF11 ELISA Standard, and as a Western Blot Control.
None at this time

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