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Bovine CX3CL1 (Fractalkine) Recombinant Protein
- Catalog Number:
- RP1126B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos indicus (zebu), Bos taurus (cattle)
- Bovine CX3CL1 (Fractalkine) (catalog RP1126B) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.6 kDa, 76 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle and zebu. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CX3CL1/fractalkine signaling and immune-cell adhesion and migration (including leukocyte trafficking and inflammatory responses); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QQHGVNKCNL FCNKMTQKIP ESRLVGYQRN RESCNDGAVI LKTVKGKSFC ADPKEEWVQK AMKHLDHKAS VSQKSG (76) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CX3CL1 (C-X3-C motif chemokine ligand 1), also known as fractalkine, is a unique chemokine that belongs to the CX3C chemokine family, distinguished by having three amino acids separating the first two conserved cysteine residues. Unlike most chemokines, CX3CL1 exists in both a membrane-bound form and a soluble form, allowing it to function in both leukocyte adhesion and chemotaxis. In cattle (Bos taurus), CX3CL1 is primarily produced by endothelial cells, epithelial cells, macrophages, and other activated tissue cells in response to inflammatory cytokines or infection. CX3CL1 binds specifically to the receptor CX3CR1, which is expressed on monocytes, macrophages, natural killer (NK) cells, and subsets of T lymphocytes, promoting recruitment, adhesion, and activation of these immune cells at sites of inflammation or tissue injury. In bovine health, CX3CL1 contributes to immune responses during bacterial and viral infections, including inflammatory conditions affecting the mammary gland, respiratory tract, and other tissues, where leukocyte recruitment is essential for pathogen clearance. Because chemokine-mediated immune cell trafficking plays an important role in host defense and inflammatory disease in cattle, bovine CX3CL1 is studied in veterinary immunology, mastitis research, and host-pathogen interaction studies to better understand mechanisms regulating immune cell migration and inflammatory responses in livestock.
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