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Bovine SCF (Stem Cell Factor) Recombinant Protein
- Catalog Number:
- RP1128B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos taurus (cattle)
- Bovine SCF (Stem Cell Factor, KIT Ligand, KITLG) (catalog RP1128B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.5 kDa, 166 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study SCF/KIT signaling and hematopoiesis (including regulation of stem cell maintenance, proliferation, and differentiation); typical experimental uses include cell-culture stimulation and differentiation assays, cytokine signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QGICSNRVTD DVKDVTKLVA NLPKDYMITL KYVPGMDVLP SHCWISEMVE QLSVSLTDLL DKFSNISEGL SNYCIIDKLV KIVDDLVECM EEHSSENVKK SSKSPEPRQF TPEKFFGIFN KSIDAFKDLE IVASKMSECV ISSTSSPEKD SRVSVTKPFM LPPVAA (166) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.5 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Stem Cell Factor (SCF) (also known as KIT ligand, KITLG, mast cell growth factor, or steel factor) is a cytokine and growth factor that plays an important role in hematopoiesis, stem cell maintenance, and immune cell development in cattle (Bos taurus). SCF belongs to a group of hematopoietic growth factors that regulate the survival, proliferation, and differentiation of stem and progenitor cells. It exerts its biological effects by binding to the c-Kit receptor (CD117), a receptor tyrosine kinase expressed on hematopoietic stem cells, mast cells, melanocytes, and germ cells, activating intracellular signaling pathways such as PI3K/AKT, MAPK, and JAK/STAT that promote cell survival and growth. In cattle, SCF is produced by stromal cells, fibroblasts, endothelial cells, and epithelial cells and exists in both membrane-bound and soluble forms, allowing both local and systemic regulation of c-Kit-expressing cells. Bovine SCF plays roles in bone marrow hematopoiesis, mast cell development, pigmentation, and reproductive cell biology, and contributes to maintenance of hematopoietic stem cell niches. Because SCF-c-Kit signaling regulates stem cell function and immune cell development, bovine SCF is studied in research on hematopoiesis, mast cell biology, reproductive physiology, and stem cell-based regenerative approaches relevant to cattle health and livestock production.
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