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Feline IL-5 Recombinant Protein
- Catalog Number:
- RP1152F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Felis catus (domestic cat), Lynx canadensis (Canada lynx), Lynx pardinus (Spanish lynx), Lynx rufus (bobcat), Puma concolor (puma)
- Feline IL-5 (Interleukin-5) (catalog RP1152F) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~13.2 kDa, 115 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat, puma, Canada lynx, bobcat, and Spanish lynx. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-5 signaling and immune responses (including regulation of eosinophil growth, differentiation, and activation); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | IAVQSPMNRL VAETLALLST HRTLLIGDGN LMIPTPEHNN HQLCIEEVFQ GIDTLKNRTV PGDAVEKLFR NLSLIKEHID RQKKKCGGER WRVKKFLDYL QVFLGVINTE WTMES (115) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 13.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline Interleukin-5 (IL-5) is a Th2-associated cytokine produced primarily by activated CD4⁺ T helper 2 (Th2) cells, mast cells, and group 2 innate lymphoid cells in cats (Felis catus), where it plays a central role in eosinophil differentiation, activation, recruitment, and survival. IL-5 is part of the common beta chain (βc) cytokine family, which also includes IL-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF); these cytokines share the βc receptor subunit and are involved in regulation of hematopoiesis and myeloid cell function. IL-5 signals through a receptor complex composed of IL-5Rα and the shared βc chain, activating JAK/STAT and MAPK pathways that promote eosinophil maturation in the bone marrow and enhance their effector functions in peripheral tissues. In feline health, IL-5 is particularly important in eosinophil-associated diseases such as feline asthma, eosinophilic granuloma complex, allergic dermatitis, food hypersensitivity, and parasitic infections, where elevated IL-5 contributes to eosinophilic airway inflammation, dermal lesions, and tissue remodeling. While IL-5-mediated responses support protective immunity against helminths, excessive or chronic IL-5 expression can drive persistent eosinophilic inflammation and tissue damage. As a biomarker of type 2 immune activation and eosinophilic disease, feline IL-5 is relevant in studies of allergic pathogenesis, vaccine responses, and immune modulation. In translational research, cats serve as valuable spontaneous models for human asthma and eosinophilic airway disorders, and characterization of feline IL-5 supports comparative investigations into βc cytokine signaling and development of targeted anti-IL-5 therapeutic strategies relevant to both veterinary and human medicine.
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