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Bovine Oncostatin M (OSM) Recombinant Protein
- Catalog Number:
- RP1182B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos taurus (cattle)
- Bovine Oncostatin M (OSM) (catalog RP1182B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~20.3 kDa, 180 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study OSM signaling and cellular responses (including regulation of inflammation, cell proliferation, and differentiation); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GKCSGKYHEL LLQLQRQADL MQDPSTLLDP YIHLQGLHSP VLQEHCRERP GDFPSEDALW RLSRQDFLQT LNTTLGLILR MLSALQQDLP EAAHQQAEMN VRGFGNNIHC MAQLLRGSSD PKAAEPTQPG PGPTPLPPTP PSSTFQRKLR NCGFLRGYHR FMRTAGQVLR GWGERQGRSR (180) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 20.3 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Oncostatin M (OSM) is a multifunctional cytokine belonging to the IL-6 family of cytokines, which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), and IL-27. In cattle (Bos taurus), OSM signals through receptor complexes containing the shared gp130 subunit, typically pairing with OSM receptor (OSMR) or LIF receptor (LIFR), leading to activation of intracellular signaling pathways such as JAK/STAT3, MAPK, and PI3K. Bovine OSM is produced primarily by activated T cells, macrophages, and neutrophils and plays roles in inflammation, hematopoiesis, and tissue remodeling. In bovine health, OSM-mediated signaling contributes to regulation of immune responses during mastitis, bovine respiratory disease complex (BRDC), and other inflammatory conditions, where it can influence leukocyte activation, cytokine production, and tissue repair. OSM may also participate in fibrotic responses and regulation of epithelial and stromal cell function during chronic inflammation. As a member of the IL-6 cytokine family involved in immune regulation and tissue remodeling, bovine OSM is important for studies of host-pathogen interactions, inflammatory disease mechanisms, and cytokine signaling pathways relevant to cattle health and productivity.
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