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Canine Oncostatin M (OSM) Recombinant Protein
- Catalog Number:
- RP1183D
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog)
- Canine Oncostatin M (OSM) (catalog RP1183D) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~20.6 kDa, 181 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to dog and dingo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study OSM signaling and cellular responses (including regulation of inflammation, cell proliferation, and differentiation); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SCSDKYPELL GQLQKQADFM QHTNTLLDLY IRSQGLDKNG LKEHCRERPG AFPSKDALQR LSRRVFLRTL DTTLGQVLLR LAALEQDIPK AQDLEMLSGV KLNIRGFKNN IHCMAQLLPG SSETTEPTPT SPGASPSPTP TLDTFQRRLE GCRFLHGYHR FMRSVGQVFR EWGKSLSRSR R (181) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 20.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine Oncostatin M (OSM) is a multifunctional cytokine belonging to the IL-6 family of cytokines, which includes IL-6, IL-11, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), and IL-27. In dogs (Canis lupus familiaris), OSM signals through receptor complexes containing the shared gp130 subunit, typically pairing with the OSM receptor (OSMR) or leukemia inhibitory factor receptor (LIFR), leading to activation of intracellular signaling pathways such as JAK/STAT3, MAPK, and PI3K. Canine OSM is produced primarily by activated T lymphocytes, macrophages, and neutrophils and functions in regulation of inflammation, hematopoiesis, and tissue remodeling. In canine health, OSM-mediated signaling is associated with inflammatory and degenerative conditions including canine osteoarthritis, dermatitis, and chronic inflammatory diseases, where it contributes to regulation of cytokine networks, matrix remodeling, and immune cell activation. OSM has also been implicated in cancer biology, including canine mammary tumors and osteosarcoma, where IL-6 family signaling pathways can influence tumor growth, tumor microenvironment remodeling, and immune responses. As a regulator of inflammation and tissue remodeling, canine OSM is important for studies of immune signaling, inflammatory disease mechanisms, and tumor biology, and contributes to comparative research using dogs as translational models for human inflammatory and musculoskeletal diseases.
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