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Ovine CCL11 (Eotaxin-1) Recombinant Protein
- Catalog Number:
- RP1192V
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Ovibos moschatus (muskox), Ovis aries (sheep)
- Ovine CCL11 (Eotaxin-1) (catalog RP1192V) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.6 kDa, 74 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to sheep and muskox. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL11/eotaxin signaling and immune-cell chemotaxis (including eosinophil recruitment and activation); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QPASIPTICC FNVSRKKISV QRLQSYRKVT GSKCPQKAVI FNTKQNKKIC VDPQEKWVQN AMEYLNQKFQ TLKS (74) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Ovine CCL11 (C-C motif chemokine ligand 11), also known as eotaxin-1, is a member of the CC chemokine family that regulates eosinophil recruitment and type 2-associated immune responses in sheep (Ovis aries). CCL11 is produced primarily by epithelial cells, fibroblasts, endothelial cells, smooth muscle cells, and activated immune cells in response to Th2-associated cytokines such as IL-4 and IL-13, as well as inflammatory stimuli. It functions predominantly through the CCR3 receptor to promote chemotaxis and activation of eosinophils, and can also influence basophils and Th2 lymphocytes. In healthy sheep, basal CCL11 expression is generally low, but levels increase during parasitic infections-particularly gastrointestinal nematode infections such as Haemonchus contortus and other helminths-as well as during allergic-type inflammation and mucosal immune activation. In veterinary and agricultural research, ovine CCL11 is an important biomarker of Th2-skewed immunity and eosinophilic inflammation, providing insight into host defense against parasites, vaccine responses, and immune regulation in small ruminant production systems.
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