Guinea Pig CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma–induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In guinea pigs (Cavia porcellus), CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), microbial infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. Guinea pigs are widely used as animal models for tuberculosis caused by Mycobacterium tuberculosis because their disease pathology closely resembles human pulmonary tuberculosis, including granuloma formation and strong Th1 immune responses. In this model, CXCL10 contributes to the recruitment of CXCR3⁺ T cells and other immune cells to infected lung tissue, making guinea pig CXCL10 an important molecule for studying interferon-driven immunity, granulomatous inflammation, and host–pathogen interactions in tuberculosis research.