Rabbit CCL5 (C–C motif chemokine ligand 5, also known as RANTES – Regulated upon Activation, Normal T cell Expressed and Secreted) is a proinflammatory chemokine that regulates immune cell recruitment and inflammatory responses in rabbits (Oryctolagus cuniculus). CCL5 is a member of the CC chemokine family, which also includes CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL2 (MCP-1), chemokines that coordinate leukocyte trafficking during immune activation. In rabbits, CCL5 is produced primarily by activated T lymphocytes, macrophages, dendritic cells, platelets, epithelial cells, and endothelial cells in response to infection, inflammatory stimuli, or tissue injury, and it exerts its biological effects mainly through binding to the chemokine receptors CCR1, CCR3, and CCR5, promoting chemotaxis and activation of T cells, monocytes/macrophages, eosinophils, and natural killer (NK) cells at sites of infection or inflammation. In rabbit health and research, CCL5 contributes to immune responses during bacterial and viral infections and plays roles in inflammatory processes and leukocyte recruitment. Because rabbits are widely used as experimental models for immunology, cardiovascular disease, and infectious disease, rabbit CCL5 is studied in host–pathogen interaction studies, inflammatory disease models, and vaccine research, helping to clarify mechanisms of chemokine-mediated immune cell trafficking and immune regulation relevant to both veterinary and human health.