Swine IFN lambda 3 (IL-28B) Recombinant Protein

Catalog Number:: RP1202S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Phacochoerus africanus (Common warthog), Sus scrofa (pig)

Swine IL-28B (Interleukin-28B, IFN-λ3) (catalog RP1202S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~19.2 kDa, 172 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig and common warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-28B/IFN-λ3 signaling and antiviral immune responses (including induction of interferon-stimulated genes and innate immune activation); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, antiviral assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	VPVPEALRAL PGARGCHLAQ FKSLSPQALQ AFKRAKDAFE ESLLEDWNCS SRIFPRSRDL KQLQVWERPV ALEAEVALTL SVLGSLANSS LHSSLDQPLH TLRHIHAQLQ ACVPAQPMAG PRPRGRLHHW LHRLQEAQKK EPQSCLEASV MFNLFRLLTR DLKCVASGDL CV (172)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	19.2 kda
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Swine interferon lambda 3 (IFN-λ3), also known as interleukin-28B (IL-28B), is a member of the type III interferon family and functions as a key antiviral cytokine that signals through the IFNLR1 (IL-28Rα)/IL-10R2 receptor complex, activating JAK/STAT pathways and inducing interferon-stimulated genes (ISGs) that restrict viral replication primarily at epithelial surfaces. In swine, IFN-λ3 plays a critical role in mucosal immunity within the respiratory and gastrointestinal tracts, major entry points for economically significant pathogens such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV). Because type III interferons generate localized antiviral protection with less systemic inflammation than type I interferons, swine IFN-λ3 is likely essential for controlling viral spread while preserving tissue integrity and growth performance. As respiratory and enteric viral diseases substantially impact global pork production, swine IFN-λ3 (IL-28B) is highly relevant for understanding antiviral defense mechanisms, improving vaccine strategies, and developing immunomodulatory approaches to enhance herd health and biosecurity.

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