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Swine SCF (Stem Cell Factor) Recombinant Protein
- Catalog Number:
- RP1203S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine SCF (Stem Cell Factor, KIT Ligand, KITLG) (catalog RP1203S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.7 kDa, 166 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study SCF/KIT signaling and hematopoiesis (including regulation of stem cell maintenance, proliferation, and differentiation); typical experimental uses include cell-culture stimulation and differentiation assays, cytokine signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QGICRNRVTD DVKDVTKLVA NLPKDYKITL KYVPGMDVLP SHCWISEMVE QLSVSLTDLL DKFSNISEGL SNYSIIDKLV KIVDDLVECM EEHSFENVRK SSKSPEPRLF TPEKFFGIFN RSIDAFKDLE MVAPKTSECV ISSTLTPEKD SRVSVTKPFM LPPVAA (166) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.7 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine Stem Cell Factor (SCF) (also known as KIT ligand, KITLG, mast cell growth factor, or steel factor) is a cytokine and growth factor that plays an important role in hematopoiesis, stem cell maintenance, and immune cell development in pigs (Sus scrofa domesticus). SCF belongs to a group of hematopoietic growth factors that regulate the survival, proliferation, and differentiation of stem and progenitor cells. It functions by binding to the c-Kit receptor (CD117), a receptor tyrosine kinase expressed on hematopoietic stem cells, mast cells, melanocytes, and germ cells, activating intracellular signaling pathways including PI3K/AKT, MAPK, and JAK/STAT that promote cell survival, proliferation, and differentiation. In pigs, SCF is produced by bone marrow stromal cells, fibroblasts, endothelial cells, and epithelial cells, and exists in both membrane-bound and soluble forms, allowing both localized and systemic regulation of c-Kit-expressing cells. Swine SCF is important for maintenance of hematopoietic stem cells within the bone marrow niche, as well as for mast cell development, pigmentation biology, and germ cell survival. Because pigs are widely used as large-animal models for human hematopoiesis, immunology, and regenerative medicine, characterization of swine SCF supports studies of stem cell regulation, immune cell development, and c-Kit-mediated signaling pathways relevant to both livestock health and translational biomedical research.
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