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Swine CBG Recombinant Protein
- Catalog Number:
- RP1208S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine CBG (Corticosteroid-Binding Globulin) (catalog RP1208S) is a yeast-derived binding protein supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.9 kDa, 163 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study corticosteroid transport and regulation (including binding and delivery of glucocorticoids and modulation of hormone bioavailability); typical experimental uses include ligand-binding and transport studies, cell-culture assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | EENFYVNETA TVKVPMMFQS RAMKYLNDSL LPCQLVQLEY TGNETAFFIL PVKGEMDTVI AGLSRDTIQR WSKSLIPSQV DLYVPKVSIS GAYDLGSILG DMGIVDLLSH PTHFSGITQN ALPKMSKVVH KAVLQFDEKG MEAAAPTTRG RSLHAAPKPV TVH (163) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine corticosteroid-binding globulin (CBG), also known as serpin A6, is a plasma glycoprotein primarily synthesized in the liver that binds and transports glucocorticoids-particularly cortisol-in pigs (Sus scrofa). CBG regulates the bioavailability of circulating cortisol by maintaining a reservoir of bound hormone, thereby controlling the fraction of free, biologically active cortisol that can interact with glucocorticoid receptors in target tissues. Under basal physiological conditions, the majority of circulating cortisol in swine is bound to CBG, with only a small proportion remaining free and active. During stress, inflammation, infection, or tissue injury, changes in CBG concentration or proteolytic cleavage of CBG can alter free cortisol levels, contributing to modulation of the hypothalamic-pituitary-adrenal (HPA) axis response. In veterinary and translational research, swine CBG is particularly relevant in studies of stress physiology, animal welfare, immune-endocrine interactions, metabolic regulation, transport stress, and inflammatory disease models. Because pigs share important physiological similarities with humans, characterization of swine CBG provides valuable insight into glucocorticoid regulation, stress adaptation, and endocrine-immune balance in both agricultural and biomedical research settings.
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